Gene and Cell Therapy
- High-performance PCR & real-time PCR systems
- Scalable liquid handling solutions
- Future-proof lab automation
The development of gene and cell therapeutic agents is very complex and costly – especially due to challenges in scaling up production and meeting strict requirements for delivery conditions and product stability. We support researchers and producers with scalable, integratable solutions to offer traceability, along with comprehensive applicative service and support. Our devices deliver unmatched precision and sensitivity on smallest footprints. Gain a competitive edge and ensure the highest product quality with our proven and trusted systems.
Products & Solutions
Highlights
- Automated end-point thermal cycling in 96 and 384 well-plate format for NGS sample preparation
- Scalable automated protein purification
- Automation under your laminar flow hood
Applications
- Sample preparation for Next Generation Sequencing
- Gene editing and gene expression
- Set-up for cell-based assays
Customer Voices
Challenging liquid handling tasks easy to achieve
“We use the Biometra TAdvanced cyclers for library preparation in Next Generation Sequencing (NGS), among other tasks. With these thermal cyclers, we consistently achieve reliable PCR results.“
Jun.-Prof. Dr. Michael Böttcher, Martin Luther University
Robust and Reliable
“The Biometra devices have proven to be very robust and reliable for complex PCR reactions.”
Prof. Dr. Ralf Küppers, University of Duisburg-Essen
Indispensible for our workflow
"The CyBio FeliX proved to be indispensible for our workflow. Particularly important for us was the fine-grained control of liqid dispensing for gentle compound additions to minimize cell disturbance."
Dr. Ralf Schwandner, CEO & Founder, Assay.Works GmbH
Applications
Gene expression and gene editing
Cell and gene therapy workflows require precise and reliable PCR — from plasmid preparation and viral vector QC to CRISPR editing and transgene analysis. Biometra thermal cyclers deliver consistent performance for critical steps like amplification and construct generation. For sensitive, multiplex qPCR, the qTOWER iris series enables accurate quantification in 96- and 384-well formats. Both technologies support automated, high-throughput workflows via their automated versions TRobot II and qTOWER3 auto — ideal for GMP-compliant development and manufacturing.
Application notes
Multiplex detection of six targets in one qPCR run using the qTOWER iris
Performing six-color probe-based qPCR without crosstalk or calibration
Set up for cell-based assays
Cell-based applications such as transfection screening, viability assays, or functional testing are essential in cell and gene therapy research. The CyBio FeliX workstation enables automated liquid handling for complex assay protocols — including media exchange, reagent addition, and magnetic bead processing. Its compact design allows placement under a laminar flow hood, ensuring contamination control for sensitive, adherent or suspension cell workflows. Empower consistency and scalability in every step of your assay setup.
Application notes
Metabolic viability assay RealTime-Glo
Multiplexed cell viability and cytotoxicity assays: RealTime-Glo, CellTox Green
Sample preparation for NGS
In cell and gene therapy research, precise characterization of vectors, edited genomes, or integration sites depends on high-quality library preparation. Optimized protocols help ensure accurate representation of target sequences, reduce amplification bias, and support reliable detection of off-target events or vector-genome junctions. Robust library prep lays the foundation for confident sequencing-based analysis in regulatory-sensitive workflows.
Application notes
Efficient Laboratory Automation
Learn about the versatile capabilities of the CyBio FeliX, including specific instrument configurations and high-throughput extraction in a compact benchtop automation setup. When paired with the ProNex® Size-Selective Purification System, the CyBio FeliX enables efficient dsDNA size selection and extraction – simple and precise. These two technologies together ensures consistent and reliable extractions for reproducible, high-quality NGS or PCR results.
Products and Solutions
Biometra endpoint thermal cyclers
- GMP-ready thermocycler software
- Fast, uniform temperature control
- Reliable performance for plasmid prep, genotyping & QC assays
qTOWERiris series
- Unique UVA-NIR range for flexible assay design
- Open system: Use any dye, labware, reagents
- Quiet, ergonomic design
Biometra TRobot II series
- Automation for 96- and 384-well plate workflows
- Fully integrable, compact and quiet
CyBio automation
- Preconfigured platforms for NGS
- Partner with 35+ years experience in thermal cycling, liquid handling and automation
CyBio Felix series
- Automation for your laminar flow hood
- Modular platform for automated plasmid extraction, transfection and other gene therapy workflows
- Precision for low-volume, high-value samples
qTOWER3 auto series
- Scalable qPCR automation for CGT labs
- Automation for high-precision results in regulated workflows
- Open format for dyes, assays, and labware
Downloads
Automated Purification of Plasmid DNA using Promega Wizard MagneSil Tfx™ System on the Analytik Jena CyBio FeliX Liquid Handler (EN)
Open PDF
Automated High-Throughput Plasmid DNA Isolation from Bacteria Cells (EN)
Open PDF
Automated PhyTip protein purification on the CyBio FeliX (EN)
Open PDF
Automated High-throughput Transformation of Bacteria Cells (EN)
Open PDFPerforming a Six-Color Probe-based Assay Without Signal Crosstalk and Calibration Effort (EN)
Open PDF
Enabling 6-Target Multiplex Real-Time PCR on qTOWER iris (EN)
Open PDFEnabling 6-Target Multiplex Real-Time PCR on qTOWER iris (EN)
Open PDF
DNA Amplicon Library Preparation for Illumina® Sequencing (EN)
Open PDF
Br NGS Library Preparation (EN)
Open PDFContact
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